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High-Throughput Skin Absorption and Penetration Technology Platform - The High-Throughput Franz Cell Technology
Zyleris has developed a first-in-class high-throughput topical and transdermal formulation screening (HTS) technology. This technology is developed based on industrial standard Franz Cell technology. It offers the best of both worlds - speed associated with high-throughput technology and yet result compatibility with the Franz Cell technology. The main technical feature includes a unique 108-cell screening station with flexibility for both skin absorption and penetration studies. It brings speed and cost efficiency to the formulation development process.
Our HTS technology is fully validated against standard Franz Cell technology. We are happy to run test formulations (free of charge, of course) for you to demonstrate our technology so you can conduct your own evaluation, comparison, and validation. Please contact us for details.
Key Technical Features
- High-throughput technology platform is designed based on static Franz Cell principle.
- Modular, compact 108-cell high-throughput screening (HTS) experimentation station (size of the station: 12x11”).
- Variable diffusion area from 0.2 to 1.1 cm2 (skin membrane diameter: 5mm to 11.5mm. The 8mm is the standard configuration).
- Glass and Teflon construction to ensure chemical inertness.
- Fast, easy, and uniform sample collection mechanism suitable for high-throughput operation.
- Controlled and efficient mixing.
- Precision temperature control.
- Applicable to all common dosage forms (gels, lotions, creams, ointments, serums/solutions, and transdermal patches).
- Animal and human tissues as well as synthetic membranes.
- Finite and infinite dose under occluded and nonoccluded conditions.
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