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Topical Formulation Development – Zyleris Pharmatech

Solubility Screening and Enhancement

Solubility screening and enhancement of drug candidates using high-throughput experimentation technology - solvents, pH, solubilizing agents, penetration enhancers, lipid vehicles, etc.

Dosage Form Selection

Based on physical and chemical properties of your compounds, select the dosage form most suitable for the compounds and intended indications - serums, ointments, gels, lotions, creams, etc.

  • Develop a dosage form to deliver your compound to targeted skin layer (topical) and systemic circulation (transdermal). For example, antifungals and keratolytics => controlled release into SC layer; anesthetics => controlled release in epidermis/dermis layer; transdermal delivery => achieve required flux across skin layers.
  • Select a dosage form compatible with intended indication of your compound. For example, antibacterials and products for atopic dermatitis and psoriasis => creams or ointments; acne and rosacea => aqueous gels.

Proof-of-Concept (POC) Formulation Development and Evaluation Starter Package

Based on physical and chemical property of your compound as well as its intended indication, 3-to-6 topical formulations in various dosage forms and/or concentration levels will be developed, The developed formulations will be evaluated for their skin absorption and penetration properties using our HTS technology platform. This package is specifically designed for a quick POC evaluation of your compound's suitability for topical and transdermal delivery. A typical turnaround time for this package is about four-to-six weeks (from receipt of testing materials to delivery of project report).