Skin absorption of an API is greatly dependent on an individual's skin. This creates a wide variety of results in an in vivo study or clinical trial that cannot be captured by a typical in vitro study with a few donors. Understanding these results is crucial to the success of a carefully crafted topical formulation. Since a clinical trial or an in vivo study of a topical formulation typically involves 100 to 500 participants, an in vitro study with 20 to 50 donors can provide valuable insights about a formulation's behavior in a larger population.
With our high-throughput Franz Cell technology and large inventory of human skin tissues, Zyleris has the capability to perform such skin absorption screening quickly and cost-efficiently.
Number of donors: 20 to 50. Number of replicates: 2 to 4. Number of Franz Cell needed for the screening: 40 to 200 cells.
We routinely conduct skin absorption studies involving those many of Franz Cells.
Typical turnaround time: four-to-six weeks.
Our customizable service allows customers to select donors that match their target treatment group and determine the number of donors that best fits their needs.